Integrins in Vascular Development
نویسندگان
چکیده
منابع مشابه
Integrins in vascular development.
Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration, proliferation, survival and differentiation of the cells that form the vasculature. Some integrins are known to be regulated by angiogenic gro...
متن کاملIntegrins in vascular development.
In recent years, there has been a sustained interest in vascularization processes. Much, if not all, of the work has included the concept of new vessel morphogenesis. Surprisingly, most of the work has not addressed developmental mechanisms directly, but rather as an offshoot of a disease process, wound healing process, or from the perspective of inducing vessels in an ischemic site. One theme ...
متن کاملIntegrins, vascular remodeling, and hypertension.
At the level of the resistance artery, hypertension also brings about a thickening of the vascular wall and inward encroachment on the lumen. This has been reported as being attributable to hypertrophy or hyperplasia of vascular smooth muscle cells (VSMCs), but studies have appeared suggesting that growth is not apparent in arteries at this level of the circulation.1 In addition, detailed struc...
متن کاملCan integrins integrate vascular myogenic responses?
Vascular pathologies associated with the heart, brain, and peripheral blood vessels remain the leading cause of death in the Western world, accounting for over 960 000 deaths in 1999 in the United States alone.1 One of the difficulties in elucidating the mechanisms contributing to vessel disease has been in fully understanding how the vascular system maintains basal vascular tone and autoregula...
متن کاملIntegrins as unique receptors for vascular control.
Cells within the vascular wall connect their cytoskeleton to the extracellular matrix (ECM) through a family of cell surface receptors known as integrins. The ability of integrins to act as a link between the extracellular and intracellular environments allows transmission of inside-out and outside-in signals capable of modulating diverse vascular phenomena. In this review we summarize what is ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh1901.097747